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NSABP Foundation sentinel lymph node biopsy (sln
Flowchart of patients according to initial cN status undergoing NAC. Bold boxes refer to excluded patients. List of abbreviations: BC—breast cancer. HCB—Hospital Clinic of Barcelona. NAC—neoadjuvant chemotherapy. c <t>—clinical.</t> <t>SLN—sentinel</t> lymph node biopsy. TAD—targeted axillary dissection. ALND—axillary lymph node dissection. US—ultrasound. MRI—magnetic resonance imaging. FNAC—fine-needle aspiration cytology. CNB—core needle biopsy.
Sentinel Lymph Node Biopsy (Sln, supplied by NSABP Foundation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sentinel+lymph+node+biopsy+(sln/sentinel+lymph+node+biopsy/pmc11545455-140-7-23
Average 90 stars, based on 1 article reviews
sentinel lymph node biopsy (sln - by Bioz Stars, 2026-09
90/100 stars

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1) Product Images from "Predicting Additional Metastases in Axillary Lymph Node Dissection After Neoadjuvant Chemotherapy: Ratio of Positive/Total Sentinel Nodes"

Article Title: Predicting Additional Metastases in Axillary Lymph Node Dissection After Neoadjuvant Chemotherapy: Ratio of Positive/Total Sentinel Nodes

Journal: Cancers

doi: 10.3390/cancers16213638

Flowchart of patients according to initial cN status undergoing NAC. Bold boxes refer to excluded patients. List of abbreviations: BC—breast cancer. HCB—Hospital Clinic of Barcelona. NAC—neoadjuvant chemotherapy. c —clinical. SLN—sentinel lymph node biopsy. TAD—targeted axillary dissection. ALND—axillary lymph node dissection. US—ultrasound. MRI—magnetic resonance imaging. FNAC—fine-needle aspiration cytology. CNB—core needle biopsy.
Figure Legend Snippet: Flowchart of patients according to initial cN status undergoing NAC. Bold boxes refer to excluded patients. List of abbreviations: BC—breast cancer. HCB—Hospital Clinic of Barcelona. NAC—neoadjuvant chemotherapy. c —clinical. SLN—sentinel lymph node biopsy. TAD—targeted axillary dissection. ALND—axillary lymph node dissection. US—ultrasound. MRI—magnetic resonance imaging. FNAC—fine-needle aspiration cytology. CNB—core needle biopsy.

Techniques Used: Dissection, Magnetic Resonance Imaging

Overall population demographics and distribution according to ALND results. Significant p values are reported in bold. a Only 2 cT4b patients fulfilled the inclusion criteria in the cT3/cT4 category; the remainder of the group is composed exclusively of cT3 patients. b For statistical analysis, RECIST criteria categories of progressive disease, stable disease and partial response have been aggregated into a non-complete response group. c Axillary US and breast/axillar MRI were performed at initial diagnosis in all patients included in the study, and breast/axillar MRI after NAC was also scheduled in all patients, except in 4 patients whose data are not available. List of abbreviations: ALND—axillary lymph node dissection;  SLN—sentinel  lymph node; SD—standard deviation; BMI—body mass index; MRI—magnetic resonance imaging; ER—estrogen receptor; PR—progesterone receptor; IHC—immunohistochemical; HR—hormonal receptor; TN—triple negative; NAC—neoadjuvant chemotherapy.
Figure Legend Snippet: Overall population demographics and distribution according to ALND results. Significant p values are reported in bold. a Only 2 cT4b patients fulfilled the inclusion criteria in the cT3/cT4 category; the remainder of the group is composed exclusively of cT3 patients. b For statistical analysis, RECIST criteria categories of progressive disease, stable disease and partial response have been aggregated into a non-complete response group. c Axillary US and breast/axillar MRI were performed at initial diagnosis in all patients included in the study, and breast/axillar MRI after NAC was also scheduled in all patients, except in 4 patients whose data are not available. List of abbreviations: ALND—axillary lymph node dissection; SLN—sentinel lymph node; SD—standard deviation; BMI—body mass index; MRI—magnetic resonance imaging; ER—estrogen receptor; PR—progesterone receptor; IHC—immunohistochemical; HR—hormonal receptor; TN—triple negative; NAC—neoadjuvant chemotherapy.

Techniques Used: Dissection, Imaging

Axillary surgery details according to ALDN results. Significant p values are reported in bold.
Figure Legend Snippet: Axillary surgery details according to ALDN results. Significant p values are reported in bold.

Techniques Used:

Patterns of SLN, SLN-R and non-SLN involvement at ALND. ( A ) Number of non-SLN affected at ALND, according to cN status at diagnosis and size of SLN metastasis in the overall population. ( B ) Pattern of non-SLN involvement after ALND, according to SLN-R cut-off ≤ 0.35. ( C ) Number of non-SLN affected at ALND, according to SLN-R cut-off ≤ 0.35 and size of SLN metastasis. ( D ) Number of non-SLN affected at ALND, according to SLN-R cut-off ≤ 0.35 within each IHC subtype. List of abbreviations: nRD—non-residual disease; RD—residual disease; IHC—immunohistochemistry; SLN—sentinel lymph node; ALND—axillary lymph node dissection; ITC—isolated tumor cells; Micro—micrometastases; Macro—macrometastases; HR—hormone receptor; + positive; − negative; TN—triple negative breast cancer. p values refer to Chi-squared tests.
Figure Legend Snippet: Patterns of SLN, SLN-R and non-SLN involvement at ALND. ( A ) Number of non-SLN affected at ALND, according to cN status at diagnosis and size of SLN metastasis in the overall population. ( B ) Pattern of non-SLN involvement after ALND, according to SLN-R cut-off ≤ 0.35. ( C ) Number of non-SLN affected at ALND, according to SLN-R cut-off ≤ 0.35 and size of SLN metastasis. ( D ) Number of non-SLN affected at ALND, according to SLN-R cut-off ≤ 0.35 within each IHC subtype. List of abbreviations: nRD—non-residual disease; RD—residual disease; IHC—immunohistochemistry; SLN—sentinel lymph node; ALND—axillary lymph node dissection; ITC—isolated tumor cells; Micro—micrometastases; Macro—macrometastases; HR—hormone receptor; + positive; − negative; TN—triple negative breast cancer. p values refer to Chi-squared tests.

Techniques Used: Immunohistochemistry, Dissection, Isolation

Related Articles

Dissection:

Article Title: Predicting Additional Metastases in Axillary Lymph Node Dissection After Neoadjuvant Chemotherapy: Ratio of Positive/Total Sentinel Nodes
Article Snippet: For clinically negative axilla (cN0) BC patients, sentinel lymph node biopsy (SLN) after NAC was proven to be feasible and safe according to NSABP-B32 trial results [ ].

Article Title: Metastasis Detection in Sentinel Lymph Nodes: Comparison of a Limited Widely Spaced (NSABP protocol B-32) and a Comprehensive Narrowly Spaced Paraffin Block Sectioning Strategy
Article Snippet: The primary aim of the National Surgical Adjuvant Breast and Bowel Project (NSABP) protocol B-32 is to determine whether patients undergoing sentinel lymph node (SLN) biopsy alone have an increased risk for axillary recurrence and decreased overall survival compared to patients undergoing complete axillary dissection ( 12 , 13 ).

Article Title: Evidence-based medicine in surgery: the importance of both experimental and observational study designs.
Article Snippet: THE INSTITUTE OF MEDICINE DEFINES THE QUALITY OF health care as the “degree to which health services for individuals and populations increase the likelihood of desired health outcomes and are consistent with current professional knowledge.” Yet for much of the 20th century, the knowledge base for surgical practice was not influenced by systematic evidence, but rather by expert opinion and collective experience.. Early attempts to scientifically measure and improve surgical quality, such as Codman’s “end result idea” in the early 1900s that sought to collect and analyze surgical outcomes, met intense resistance.. Fortunately, evidence-based medicine in surgery has now been thoroughly accepted; sophisticated researchers are applying a variety of study designs and methodological techniques to answer an expansive number of important clinical questions.

Article Title: How Do Pathologists in Academic Institutions Across the United States and Canada Evaluate Sentinel Lymph Nodes in Breast Cancer? A Practice Survey.
Article Snippet: Objectives: There are little data on how changes in the clinical management of axillary lymph nodes in breast cancer have influenced pathologist evaluation of sentinel

Magnetic Resonance Imaging:

Article Title: Predicting Additional Metastases in Axillary Lymph Node Dissection After Neoadjuvant Chemotherapy: Ratio of Positive/Total Sentinel Nodes
Article Snippet: For clinically negative axilla (cN0) BC patients, sentinel lymph node biopsy (SLN) after NAC was proven to be feasible and safe according to NSABP-B32 trial results [ ].

Article Title: Metastasis Detection in Sentinel Lymph Nodes: Comparison of a Limited Widely Spaced (NSABP protocol B-32) and a Comprehensive Narrowly Spaced Paraffin Block Sectioning Strategy
Article Snippet: The primary aim of the National Surgical Adjuvant Breast and Bowel Project (NSABP) protocol B-32 is to determine whether patients undergoing sentinel lymph node (SLN) biopsy alone have an increased risk for axillary recurrence and decreased overall survival compared to patients undergoing complete axillary dissection ( 12 , 13 ).

Article Title: Evidence-based medicine in surgery: the importance of both experimental and observational study designs.
Article Snippet: THE INSTITUTE OF MEDICINE DEFINES THE QUALITY OF health care as the “degree to which health services for individuals and populations increase the likelihood of desired health outcomes and are consistent with current professional knowledge.” Yet for much of the 20th century, the knowledge base for surgical practice was not influenced by systematic evidence, but rather by expert opinion and collective experience.. Early attempts to scientifically measure and improve surgical quality, such as Codman’s “end result idea” in the early 1900s that sought to collect and analyze surgical outcomes, met intense resistance.. Fortunately, evidence-based medicine in surgery has now been thoroughly accepted; sophisticated researchers are applying a variety of study designs and methodological techniques to answer an expansive number of important clinical questions.

Article Title: How Do Pathologists in Academic Institutions Across the United States and Canada Evaluate Sentinel Lymph Nodes in Breast Cancer? A Practice Survey.
Article Snippet: Objectives: There are little data on how changes in the clinical management of axillary lymph nodes in breast cancer have influenced pathologist evaluation of sentinel

Imaging:

Article Title: Predicting Additional Metastases in Axillary Lymph Node Dissection After Neoadjuvant Chemotherapy: Ratio of Positive/Total Sentinel Nodes
Article Snippet: For clinically negative axilla (cN0) BC patients, sentinel lymph node biopsy (SLN) after NAC was proven to be feasible and safe according to NSABP-B32 trial results [ ].

Article Title: Metastasis Detection in Sentinel Lymph Nodes: Comparison of a Limited Widely Spaced (NSABP protocol B-32) and a Comprehensive Narrowly Spaced Paraffin Block Sectioning Strategy
Article Snippet: The primary aim of the National Surgical Adjuvant Breast and Bowel Project (NSABP) protocol B-32 is to determine whether patients undergoing sentinel lymph node (SLN) biopsy alone have an increased risk for axillary recurrence and decreased overall survival compared to patients undergoing complete axillary dissection ( 12 , 13 ).

Article Title: Evidence-based medicine in surgery: the importance of both experimental and observational study designs.
Article Snippet: THE INSTITUTE OF MEDICINE DEFINES THE QUALITY OF health care as the “degree to which health services for individuals and populations increase the likelihood of desired health outcomes and are consistent with current professional knowledge.” Yet for much of the 20th century, the knowledge base for surgical practice was not influenced by systematic evidence, but rather by expert opinion and collective experience.. Early attempts to scientifically measure and improve surgical quality, such as Codman’s “end result idea” in the early 1900s that sought to collect and analyze surgical outcomes, met intense resistance.. Fortunately, evidence-based medicine in surgery has now been thoroughly accepted; sophisticated researchers are applying a variety of study designs and methodological techniques to answer an expansive number of important clinical questions.

Article Title: How Do Pathologists in Academic Institutions Across the United States and Canada Evaluate Sentinel Lymph Nodes in Breast Cancer? A Practice Survey.
Article Snippet: Objectives: There are little data on how changes in the clinical management of axillary lymph nodes in breast cancer have influenced pathologist evaluation of sentinel

Immunohistochemistry:

Article Title: Predicting Additional Metastases in Axillary Lymph Node Dissection After Neoadjuvant Chemotherapy: Ratio of Positive/Total Sentinel Nodes
Article Snippet: For clinically negative axilla (cN0) BC patients, sentinel lymph node biopsy (SLN) after NAC was proven to be feasible and safe according to NSABP-B32 trial results [ ].

Article Title: Metastasis Detection in Sentinel Lymph Nodes: Comparison of a Limited Widely Spaced (NSABP protocol B-32) and a Comprehensive Narrowly Spaced Paraffin Block Sectioning Strategy
Article Snippet: The primary aim of the National Surgical Adjuvant Breast and Bowel Project (NSABP) protocol B-32 is to determine whether patients undergoing sentinel lymph node (SLN) biopsy alone have an increased risk for axillary recurrence and decreased overall survival compared to patients undergoing complete axillary dissection ( 12 , 13 ).

Article Title: Evidence-based medicine in surgery: the importance of both experimental and observational study designs.
Article Snippet: THE INSTITUTE OF MEDICINE DEFINES THE QUALITY OF health care as the “degree to which health services for individuals and populations increase the likelihood of desired health outcomes and are consistent with current professional knowledge.” Yet for much of the 20th century, the knowledge base for surgical practice was not influenced by systematic evidence, but rather by expert opinion and collective experience.. Early attempts to scientifically measure and improve surgical quality, such as Codman’s “end result idea” in the early 1900s that sought to collect and analyze surgical outcomes, met intense resistance.. Fortunately, evidence-based medicine in surgery has now been thoroughly accepted; sophisticated researchers are applying a variety of study designs and methodological techniques to answer an expansive number of important clinical questions.

Article Title: How Do Pathologists in Academic Institutions Across the United States and Canada Evaluate Sentinel Lymph Nodes in Breast Cancer? A Practice Survey.
Article Snippet: Objectives: There are little data on how changes in the clinical management of axillary lymph nodes in breast cancer have influenced pathologist evaluation of sentinel

Isolation:

Article Title: Predicting Additional Metastases in Axillary Lymph Node Dissection After Neoadjuvant Chemotherapy: Ratio of Positive/Total Sentinel Nodes
Article Snippet: For clinically negative axilla (cN0) BC patients, sentinel lymph node biopsy (SLN) after NAC was proven to be feasible and safe according to NSABP-B32 trial results [ ].

Article Title: Metastasis Detection in Sentinel Lymph Nodes: Comparison of a Limited Widely Spaced (NSABP protocol B-32) and a Comprehensive Narrowly Spaced Paraffin Block Sectioning Strategy
Article Snippet: The primary aim of the National Surgical Adjuvant Breast and Bowel Project (NSABP) protocol B-32 is to determine whether patients undergoing sentinel lymph node (SLN) biopsy alone have an increased risk for axillary recurrence and decreased overall survival compared to patients undergoing complete axillary dissection ( 12 , 13 ).

Article Title: Evidence-based medicine in surgery: the importance of both experimental and observational study designs.
Article Snippet: THE INSTITUTE OF MEDICINE DEFINES THE QUALITY OF health care as the “degree to which health services for individuals and populations increase the likelihood of desired health outcomes and are consistent with current professional knowledge.” Yet for much of the 20th century, the knowledge base for surgical practice was not influenced by systematic evidence, but rather by expert opinion and collective experience.. Early attempts to scientifically measure and improve surgical quality, such as Codman’s “end result idea” in the early 1900s that sought to collect and analyze surgical outcomes, met intense resistance.. Fortunately, evidence-based medicine in surgery has now been thoroughly accepted; sophisticated researchers are applying a variety of study designs and methodological techniques to answer an expansive number of important clinical questions.

Article Title: How Do Pathologists in Academic Institutions Across the United States and Canada Evaluate Sentinel Lymph Nodes in Breast Cancer? A Practice Survey.
Article Snippet: Objectives: There are little data on how changes in the clinical management of axillary lymph nodes in breast cancer have influenced pathologist evaluation of sentinel

Adjuvant:

Article Title: Predicting Additional Metastases in Axillary Lymph Node Dissection After Neoadjuvant Chemotherapy: Ratio of Positive/Total Sentinel Nodes
Article Snippet: For clinically negative axilla (cN0) BC patients, sentinel lymph node biopsy (SLN) after NAC was proven to be feasible and safe according to NSABP-B32 trial results [ ].

Article Title: Metastasis Detection in Sentinel Lymph Nodes: Comparison of a Limited Widely Spaced (NSABP protocol B-32) and a Comprehensive Narrowly Spaced Paraffin Block Sectioning Strategy
Article Snippet: The primary aim of the National Surgical Adjuvant Breast and Bowel Project (NSABP) protocol B-32 is to determine whether patients undergoing sentinel lymph node (SLN) biopsy alone have an increased risk for axillary recurrence and decreased overall survival compared to patients undergoing complete axillary dissection ( 12 , 13 ).

Article Title: Evidence-based medicine in surgery: the importance of both experimental and observational study designs.
Article Snippet: THE INSTITUTE OF MEDICINE DEFINES THE QUALITY OF health care as the “degree to which health services for individuals and populations increase the likelihood of desired health outcomes and are consistent with current professional knowledge.” Yet for much of the 20th century, the knowledge base for surgical practice was not influenced by systematic evidence, but rather by expert opinion and collective experience.. Early attempts to scientifically measure and improve surgical quality, such as Codman’s “end result idea” in the early 1900s that sought to collect and analyze surgical outcomes, met intense resistance.. Fortunately, evidence-based medicine in surgery has now been thoroughly accepted; sophisticated researchers are applying a variety of study designs and methodological techniques to answer an expansive number of important clinical questions.

Article Title: How Do Pathologists in Academic Institutions Across the United States and Canada Evaluate Sentinel Lymph Nodes in Breast Cancer? A Practice Survey.
Article Snippet: Objectives: There are little data on how changes in the clinical management of axillary lymph nodes in breast cancer have influenced pathologist evaluation of sentinel

Clinical Proteomics:

Article Title: Predicting Additional Metastases in Axillary Lymph Node Dissection After Neoadjuvant Chemotherapy: Ratio of Positive/Total Sentinel Nodes
Article Snippet: For clinically negative axilla (cN0) BC patients, sentinel lymph node biopsy (SLN) after NAC was proven to be feasible and safe according to NSABP-B32 trial results [ ].

Article Title: Metastasis Detection in Sentinel Lymph Nodes: Comparison of a Limited Widely Spaced (NSABP protocol B-32) and a Comprehensive Narrowly Spaced Paraffin Block Sectioning Strategy
Article Snippet: The primary aim of the National Surgical Adjuvant Breast and Bowel Project (NSABP) protocol B-32 is to determine whether patients undergoing sentinel lymph node (SLN) biopsy alone have an increased risk for axillary recurrence and decreased overall survival compared to patients undergoing complete axillary dissection ( 12 , 13 ).

Article Title: Evidence-based medicine in surgery: the importance of both experimental and observational study designs.
Article Snippet: THE INSTITUTE OF MEDICINE DEFINES THE QUALITY OF health care as the “degree to which health services for individuals and populations increase the likelihood of desired health outcomes and are consistent with current professional knowledge.” Yet for much of the 20th century, the knowledge base for surgical practice was not influenced by systematic evidence, but rather by expert opinion and collective experience.. Early attempts to scientifically measure and improve surgical quality, such as Codman’s “end result idea” in the early 1900s that sought to collect and analyze surgical outcomes, met intense resistance.. Fortunately, evidence-based medicine in surgery has now been thoroughly accepted; sophisticated researchers are applying a variety of study designs and methodological techniques to answer an expansive number of important clinical questions.

Article Title: How Do Pathologists in Academic Institutions Across the United States and Canada Evaluate Sentinel Lymph Nodes in Breast Cancer? A Practice Survey.
Article Snippet: Objectives: There are little data on how changes in the clinical management of axillary lymph nodes in breast cancer have influenced pathologist evaluation of sentinel

Control:

Article Title: Predicting Additional Metastases in Axillary Lymph Node Dissection After Neoadjuvant Chemotherapy: Ratio of Positive/Total Sentinel Nodes
Article Snippet: For clinically negative axilla (cN0) BC patients, sentinel lymph node biopsy (SLN) after NAC was proven to be feasible and safe according to NSABP-B32 trial results [ ].

Article Title: Metastasis Detection in Sentinel Lymph Nodes: Comparison of a Limited Widely Spaced (NSABP protocol B-32) and a Comprehensive Narrowly Spaced Paraffin Block Sectioning Strategy
Article Snippet: The primary aim of the National Surgical Adjuvant Breast and Bowel Project (NSABP) protocol B-32 is to determine whether patients undergoing sentinel lymph node (SLN) biopsy alone have an increased risk for axillary recurrence and decreased overall survival compared to patients undergoing complete axillary dissection ( 12 , 13 ).

Article Title: Evidence-based medicine in surgery: the importance of both experimental and observational study designs.
Article Snippet: THE INSTITUTE OF MEDICINE DEFINES THE QUALITY OF health care as the “degree to which health services for individuals and populations increase the likelihood of desired health outcomes and are consistent with current professional knowledge.” Yet for much of the 20th century, the knowledge base for surgical practice was not influenced by systematic evidence, but rather by expert opinion and collective experience.. Early attempts to scientifically measure and improve surgical quality, such as Codman’s “end result idea” in the early 1900s that sought to collect and analyze surgical outcomes, met intense resistance.. Fortunately, evidence-based medicine in surgery has now been thoroughly accepted; sophisticated researchers are applying a variety of study designs and methodological techniques to answer an expansive number of important clinical questions.

Article Title: How Do Pathologists in Academic Institutions Across the United States and Canada Evaluate Sentinel Lymph Nodes in Breast Cancer? A Practice Survey.
Article Snippet: Objectives: There are little data on how changes in the clinical management of axillary lymph nodes in breast cancer have influenced pathologist evaluation of sentinel

Comparison:

Article Title: Predicting Additional Metastases in Axillary Lymph Node Dissection After Neoadjuvant Chemotherapy: Ratio of Positive/Total Sentinel Nodes
Article Snippet: For clinically negative axilla (cN0) BC patients, sentinel lymph node biopsy (SLN) after NAC was proven to be feasible and safe according to NSABP-B32 trial results [ ].

Article Title: Metastasis Detection in Sentinel Lymph Nodes: Comparison of a Limited Widely Spaced (NSABP protocol B-32) and a Comprehensive Narrowly Spaced Paraffin Block Sectioning Strategy
Article Snippet: The primary aim of the National Surgical Adjuvant Breast and Bowel Project (NSABP) protocol B-32 is to determine whether patients undergoing sentinel lymph node (SLN) biopsy alone have an increased risk for axillary recurrence and decreased overall survival compared to patients undergoing complete axillary dissection ( 12 , 13 ).

Article Title: Evidence-based medicine in surgery: the importance of both experimental and observational study designs.
Article Snippet: THE INSTITUTE OF MEDICINE DEFINES THE QUALITY OF health care as the “degree to which health services for individuals and populations increase the likelihood of desired health outcomes and are consistent with current professional knowledge.” Yet for much of the 20th century, the knowledge base for surgical practice was not influenced by systematic evidence, but rather by expert opinion and collective experience.. Early attempts to scientifically measure and improve surgical quality, such as Codman’s “end result idea” in the early 1900s that sought to collect and analyze surgical outcomes, met intense resistance.. Fortunately, evidence-based medicine in surgery has now been thoroughly accepted; sophisticated researchers are applying a variety of study designs and methodological techniques to answer an expansive number of important clinical questions.

Article Title: How Do Pathologists in Academic Institutions Across the United States and Canada Evaluate Sentinel Lymph Nodes in Breast Cancer? A Practice Survey.
Article Snippet: Objectives: There are little data on how changes in the clinical management of axillary lymph nodes in breast cancer have influenced pathologist evaluation of sentinel



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Image Search Results


Flowchart of patients according to initial cN status undergoing NAC. Bold boxes refer to excluded patients. List of abbreviations: BC—breast cancer. HCB—Hospital Clinic of Barcelona. NAC—neoadjuvant chemotherapy. c —clinical. SLN—sentinel lymph node biopsy. TAD—targeted axillary dissection. ALND—axillary lymph node dissection. US—ultrasound. MRI—magnetic resonance imaging. FNAC—fine-needle aspiration cytology. CNB—core needle biopsy.

Journal: Cancers

Article Title: Predicting Additional Metastases in Axillary Lymph Node Dissection After Neoadjuvant Chemotherapy: Ratio of Positive/Total Sentinel Nodes

doi: 10.3390/cancers16213638

Figure Lengend Snippet: Flowchart of patients according to initial cN status undergoing NAC. Bold boxes refer to excluded patients. List of abbreviations: BC—breast cancer. HCB—Hospital Clinic of Barcelona. NAC—neoadjuvant chemotherapy. c —clinical. SLN—sentinel lymph node biopsy. TAD—targeted axillary dissection. ALND—axillary lymph node dissection. US—ultrasound. MRI—magnetic resonance imaging. FNAC—fine-needle aspiration cytology. CNB—core needle biopsy.

Article Snippet: For clinically negative axilla (cN0) BC patients, sentinel lymph node biopsy (SLN) after NAC was proven to be feasible and safe according to NSABP-B32 trial results [ ].

Techniques: Dissection, Magnetic Resonance Imaging

Overall population demographics and distribution according to ALND results. Significant p values are reported in bold. a Only 2 cT4b patients fulfilled the inclusion criteria in the cT3/cT4 category; the remainder of the group is composed exclusively of cT3 patients. b For statistical analysis, RECIST criteria categories of progressive disease, stable disease and partial response have been aggregated into a non-complete response group. c Axillary US and breast/axillar MRI were performed at initial diagnosis in all patients included in the study, and breast/axillar MRI after NAC was also scheduled in all patients, except in 4 patients whose data are not available. List of abbreviations: ALND—axillary lymph node dissection;  SLN—sentinel  lymph node; SD—standard deviation; BMI—body mass index; MRI—magnetic resonance imaging; ER—estrogen receptor; PR—progesterone receptor; IHC—immunohistochemical; HR—hormonal receptor; TN—triple negative; NAC—neoadjuvant chemotherapy.

Journal: Cancers

Article Title: Predicting Additional Metastases in Axillary Lymph Node Dissection After Neoadjuvant Chemotherapy: Ratio of Positive/Total Sentinel Nodes

doi: 10.3390/cancers16213638

Figure Lengend Snippet: Overall population demographics and distribution according to ALND results. Significant p values are reported in bold. a Only 2 cT4b patients fulfilled the inclusion criteria in the cT3/cT4 category; the remainder of the group is composed exclusively of cT3 patients. b For statistical analysis, RECIST criteria categories of progressive disease, stable disease and partial response have been aggregated into a non-complete response group. c Axillary US and breast/axillar MRI were performed at initial diagnosis in all patients included in the study, and breast/axillar MRI after NAC was also scheduled in all patients, except in 4 patients whose data are not available. List of abbreviations: ALND—axillary lymph node dissection; SLN—sentinel lymph node; SD—standard deviation; BMI—body mass index; MRI—magnetic resonance imaging; ER—estrogen receptor; PR—progesterone receptor; IHC—immunohistochemical; HR—hormonal receptor; TN—triple negative; NAC—neoadjuvant chemotherapy.

Article Snippet: For clinically negative axilla (cN0) BC patients, sentinel lymph node biopsy (SLN) after NAC was proven to be feasible and safe according to NSABP-B32 trial results [ ].

Techniques: Dissection, Imaging

Axillary surgery details according to ALDN results. Significant p values are reported in bold.

Journal: Cancers

Article Title: Predicting Additional Metastases in Axillary Lymph Node Dissection After Neoadjuvant Chemotherapy: Ratio of Positive/Total Sentinel Nodes

doi: 10.3390/cancers16213638

Figure Lengend Snippet: Axillary surgery details according to ALDN results. Significant p values are reported in bold.

Article Snippet: For clinically negative axilla (cN0) BC patients, sentinel lymph node biopsy (SLN) after NAC was proven to be feasible and safe according to NSABP-B32 trial results [ ].

Techniques:

Patterns of SLN, SLN-R and non-SLN involvement at ALND. ( A ) Number of non-SLN affected at ALND, according to cN status at diagnosis and size of SLN metastasis in the overall population. ( B ) Pattern of non-SLN involvement after ALND, according to SLN-R cut-off ≤ 0.35. ( C ) Number of non-SLN affected at ALND, according to SLN-R cut-off ≤ 0.35 and size of SLN metastasis. ( D ) Number of non-SLN affected at ALND, according to SLN-R cut-off ≤ 0.35 within each IHC subtype. List of abbreviations: nRD—non-residual disease; RD—residual disease; IHC—immunohistochemistry; SLN—sentinel lymph node; ALND—axillary lymph node dissection; ITC—isolated tumor cells; Micro—micrometastases; Macro—macrometastases; HR—hormone receptor; + positive; − negative; TN—triple negative breast cancer. p values refer to Chi-squared tests.

Journal: Cancers

Article Title: Predicting Additional Metastases in Axillary Lymph Node Dissection After Neoadjuvant Chemotherapy: Ratio of Positive/Total Sentinel Nodes

doi: 10.3390/cancers16213638

Figure Lengend Snippet: Patterns of SLN, SLN-R and non-SLN involvement at ALND. ( A ) Number of non-SLN affected at ALND, according to cN status at diagnosis and size of SLN metastasis in the overall population. ( B ) Pattern of non-SLN involvement after ALND, according to SLN-R cut-off ≤ 0.35. ( C ) Number of non-SLN affected at ALND, according to SLN-R cut-off ≤ 0.35 and size of SLN metastasis. ( D ) Number of non-SLN affected at ALND, according to SLN-R cut-off ≤ 0.35 within each IHC subtype. List of abbreviations: nRD—non-residual disease; RD—residual disease; IHC—immunohistochemistry; SLN—sentinel lymph node; ALND—axillary lymph node dissection; ITC—isolated tumor cells; Micro—micrometastases; Macro—macrometastases; HR—hormone receptor; + positive; − negative; TN—triple negative breast cancer. p values refer to Chi-squared tests.

Article Snippet: For clinically negative axilla (cN0) BC patients, sentinel lymph node biopsy (SLN) after NAC was proven to be feasible and safe according to NSABP-B32 trial results [ ].

Techniques: Immunohistochemistry, Dissection, Isolation